Dansk Lagotto Klub

Klubben for Lagotto Romagnolo

Svar på gentests

 Hunden er blevet gentestet og svaret kommer, men hvordan skal det forstås?

 

Dyrlaege                                 LABOKLIN GmbH&CoKG
Hans Joergen Pedersen                    Steubenstraβe 4
Stadion Allé 27                          DE-97688 Bad Kissingen
7100 Vejle                               Fax-Nr.: +49 971 68546
Dänemark                                 Tel.:    +49 971 72020

                                         Report
                                         No.: 1602-W-05680
                                         Date of arrival: 18-02-2016
                                         Date of report:  23-02-2016
+----------------------------------------------------------------+
| Patient identification: Dog          Female         * 08.03.13 |
|                         Lagotto Romagnolo                      |
| Owner / Animal-ID:      Tandrup Lauridsen, Mette (2109)        |
| Type of sample:         EDTA-Blood                             |
| Date sample was taken:  15-02-2016                             |
+----------------------------------------------------------------+
       
 Parameter               Value                  Reference value

 Name:               Angelus Mei Giria                                                      
 Stud book no.:      DK 10637/2013                                                          
 Chip no.:           900118000099129                                                        
 Tattoo no.:              ---                                                               
     
 Juvenile Epilepsy
 Result: Genotype N/JE
 
 Interpretation: The examined animal is heterozygous for the 
 causative mutation for JE in the LGI2-gene.
 
 Trait of inheritance: autosomal-recessive 
 
 Scientific studies found correlation between the mutation and 
 symptoms of the disease in the following breeds: 
 Lagotto Romagnolo
 
Lagotto Speicherkrankheit (LSD) - PCR

 Result: Genotype N/LSD
 
 Interpretation: The examined animal is heterozygous for the 
 causative mutation for LSD in the ATG4D-gene.
 
 Trait of inheritance: autosomal-recessive 
 
 Scientific studies found correlation between the mutation and 
 symptoms of the disease in the following breeds: Lagotto Romagnolo
      
Furnishing - PCR
 Result: Genotype F/F
 
 Interpretation: The examined animal is homozygous for the
 F-allele.
 
 The test detects the alleles F (furnished) and f (un-furnished).
 Allelic series: F dominant over f
 


You have requested a certificate for the ordered genetic testing. 
Please thoroughly verify the animal and owner data provided to you. 
Any corrections afterward can only be carried out by the end of 
the following month, strictly in accordance with prior written 
confirmation from the veterinarian. Please note that an extra 
charge will be invoiced separately upon changes to an already 
issued certificate.
                                                                                            
                                                                                     
*** END of report *** 
                                        Hr.Dr. Beitzinger
                                        Dipl.-Biol. Molekularbiologie


Ud fra prøverne er hunhunden (Ria) bærer af LSD og JE. Fri ved Furnishing.

Clear

Genotype: N / N [  Homozygous normal ] 

The dog is noncarrier of the mutant gene.

The dog will never develop Juvenile epilepsy and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / JE [  Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

The dog will never develop Juvenile epilepsy but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. 

Carriers should only be bred to clear dogs. 

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

 

Affected

Genotype:  JE / JE [  Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog will develop Juvenile epilepsy and will pass the mutant gene to its entire offspring


Skemaoversigt over arvelighed, hvis hunden er bærer af en genmutation

Trait of Inheritance 

Autosomal recessive


Inheritance : AUTOSOMAL RECESSIVE trait

Sire

 

Dam

 

Offspring

 

 

 

 

 

clear

http://www.laboklin.co.uk/images/x.png

clear

http://www.laboklin.co.uk/images/GreaterThan.png

100% clear

 

 

 

 

 

clear

http://www.laboklin.co.uk/images/x.png

carrier

http://www.laboklin.co.uk/images/GreaterThan.png

50%  clear + 50% carriers

 

 

 

 

 

clear

http://www.laboklin.co.uk/images/x.png

affected

http://www.laboklin.co.uk/images/GreaterThan.png

100% carriers

 

 

 

 

 

carrier

http://www.laboklin.co.uk/images/x.png

clear

http://www.laboklin.co.uk/images/GreaterThan.png

50%  clear + 50% carriers

 

 

 

 

 

carrier

http://www.laboklin.co.uk/images/x.png

carrier

http://www.laboklin.co.uk/images/GreaterThan.png

25% clear + 25% affected + 50% carriers

 

 

 

 

 

carrier

http://www.laboklin.co.uk/images/x.png

affected

http://www.laboklin.co.uk/images/GreaterThan.png

50% carriers + 50% affected

 

 

 

 

 

affected

http://www.laboklin.co.uk/images/x.png

clear

http://www.laboklin.co.uk/images/GreaterThan.png

100%  carriers

 

 

 

 

 

affected

http://www.laboklin.co.uk/images/x.png

carrier

http://www.laboklin.co.uk/images/GreaterThan.png

50% carriers + 50% affected

 

 

 

 

 

affected

http://www.laboklin.co.uk/images/x.png

affected

http://www.laboklin.co.uk/images/GreaterThan.png

100% affected

 




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