Skemaoversigt over arvelighed, hvis hunden er bærer af en genmutation
Trait of Inheritance |
Autosomal recessive |
Inheritance : AUTOSOMAL RECESSIVE trait
Sire | | Dam | | Offspring | | | | | | clear | 
| clear | 
| 100% clear | | | | | | clear | 
| carrier |
| 50% clear + 50% carriers | | | | | | clear |
| affected | 
| 100% carriers | | | | | | carrier |
| clear |
| 50% clear + 50% carriers | | | | | | carrier |
| carrier |
| 25% clear + 25% affected + 50% carriers | | | | | | carrier |
| affected |
| 50% carriers + 50% affected | | | | | | affected |
| clear |
| 100% carriers | | | | | | affected |
| carrier |
| 50% carriers + 50% affected | | | | | | affected |
| affected |
| 100% affected |
|
|
Et eksempel:
Hunden er blevet gentestet og svaret kommer, men hvordan skal det forstås?
Dyrlaege LABOKLIN GmbH&CoKG
NN Steubenstraβe 4
Adresse DE-97688 Bad Kissingen
By Fax-Nr.: +49 971 68546
Dänemark Tel.: +49 971 72020
Report
No.: 1602-W-05680
Date of arrival: 18-02-2016
Date of report: 23-02-2016
+----------------------------------------------------------------+
| Patient identification: Dog Female * 08.03.13 |
| Lagotto Romagnolo |
| Owner / Animal-ID: XXXXX (2109) |
| Type of sample: EDTA-Blood |
| Date sample was taken: 15-02-2016 |
+----------------------------------------------------------------+
Parameter Value Reference value
Name: AMG
Stud book no.: DK xxxxx/2013
Chip no.: 9001xxxxxxxxxxx
Tattoo no.: ---
Juvenile Epilepsy
Result: Genotype N/JE
Interpretation: The examined animal is heterozygous for the
causative mutation for JE in the LGI2-gene.
Trait of inheritance: autosomal-recessive
Scientific studies found correlation between the mutation and
symptoms of the disease in the following breeds:
Lagotto Romagnolo
Lagotto Speicherkrankheit (LSD) - PCR
Result: Genotype N/LSD
Interpretation: The examined animal is heterozygous for the
causative mutation for LSD in the ATG4D-gene.
Trait of inheritance: autosomal-recessive
Scientific studies found correlation between the mutation and
symptoms of the disease in the following breeds: Lagotto Romagnolo
Furnishing - PCR
Result: Genotype F/F
Interpretation: The examined animal is homozygous for the
F-allele.
The test detects the alleles F (furnished) and f (un-furnished).
Allelic series: F dominant over f
You have requested a certificate for the ordered genetic testing.
Please thoroughly verify the animal and owner data provided to you.
Any corrections afterward can only be carried out by the end of
the following month, strictly in accordance with prior written
confirmation from the veterinarian. Please note that an extra
charge will be invoiced separately upon changes to an already
issued certificate.
*** END of report ***
Hr.Dr. Beitzinger
Dipl.-Biol. Molekularbiologie
Ud fra prøverne er hunhunden (navn) bærer af LSD og JE. Fri ved Furnishing.
Clear
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
The dog will never develop Juvenile epilepsy and therefore it can be bred to any other dog.
Carrier
Genotype: N / JE [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene.
The dog will never develop Juvenile epilepsy but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected
Genotype: JE / JE [ Homozygous mutant ]
The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog will develop Juvenile epilepsy and will pass the mutant gene to its entire offspring